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Bringing Cytokine Signalling to Clinical Practice: Highlights from EULAR 2017

Developed by CESAS Medical, under the auspices of the University of Glasgow
This activity is supported by unrestricted educational grants from Pfizer Italia S.R.L., Lilly and R-Pharm

Release date: 14 July 2017
Estimated time to complete activity: 2 hours 30 minutes
Compatible with all modern internet browsers and mobile devices

EDUCATIONAL OBJECTIVES
After completing this activity, the learner will:
  • Be familiar with the latest clinical data relating to cytokine signalling science from EULAR 2017
  • Understand how these data are likely to affect treatment decisions and impact clinical practice

TARGET AUDIENCE
This activity is designed for qualified rheumatologists of all levels of seniority, and other healthcare professionals involved in treating patients with rheumatic disease.

PROGRAMME OVERVIEW
EULAR 2017 presented new scientific and clinical information on cytokine signalling science and IL-6 science that will shape the rheumatology treatment landscape. Data presented included those relating to recently approved cytokine signalling agents and those currently in development.

In this activity Bringing Cytokine Signalling to Clinical Practice: Highlights from EULAR 2017, a panel of international experts discuss key abstracts and data from EULAR 2017 specifically relating to cytokine signalling science.

With recent approval of new cytokine signalling agents, and other agents now moving into Phase 2/3 trials, there is an educational need for physicians to stay abreast of ongoing research, and understand the potential impact of these new data on clinical practice. Targeting the cytokine signalling pathway as a treatment for inflammatory diseases, including rheumatoid arthritis and psoriatic arthritis, remains at the forefront of scientific development. New agents with the potential for great benefit to patients have moved from clinical trials into clinical practice, and real-world data are now becoming available.

This course Bringing Cytokine Signalling to Clinical Practice: Highlights from EULAR 2017 outlines recent developments in cytokine signalling science, and highlights and discusses the importance of these new data for clinical practice. The learner’s understanding of the information presented will be assessed following each of the course modules.

INSTRUCTIONS FOR PARTICIPATION
Participants must 1) read the activity information; 2) study the educational activity; 3) successfully complete the post-module assessments with a score of 80% or better; 4) and complete the evaluation form. Upon completion of the full activity, your certificate will be made available to download and print.

DISCLOSURE OF CONFLICTS OF INTEREST
CESAS Medical requires faculty, presenters, planners, managers, writers, and any other individuals who are in a position to influence the content of this activity to disclose any real and/or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly reviewed and resolved according to CESAS Medical policy.

Please note that this course is currently awaiting accreditation.


View congress highlights


Module Presenter Video Questions
Introduction
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
02:14
EULAR 2017 – Long-term Extension Studies and Real-world Data
Professor Christopher Edwards image
Professor Christopher Edwards

Honorary Chair of Clinical Rheumatology,
University of Southampton, Southampton, UK

Professor Christopher Edwards is Consultant Rheumatologist and Honorary Chair of Clinical Rheumatology, University Hospital Southampton NHS Foundation Trust within Medicine at the University of Southampton. He graduated with honors from King's College London and trained at the Hammersmith and St George's Hospitals in London. He was a registrar for Professor Graham Hughes at the St Thomas' Hospital lupus unit and then undertook a period of research as a lecturer at the Kennedy Institute of Rheumatology at Imperial College under the supervision of Professor Ravinder Maini. He moved to Southampton in 2001 after working for a year as a rheumatology consultant at Tan Tock Seng Hospital in Singapore.

Professor Edwards is a clinical rheumatologist with research interests and expertise in the epidemiology and treatment of inflammatory rheumatic diseases including rheumatoid arthritis, lupus, psoriatic arthritis and ankylosing spondylitis.

He is a member of international committees working to produce guidelines for the best management of rheumatic diseases, leading a systematic review of guidelines for the use of radiology in the diagnosis and management of rheumatoid arthritis for EULAR. With expertise in the planning and delivery of trials in this area, including early stage trials, Professor Edwards has developed strong local and international partnerships with clinical and academic colleagues, centered on his role as clinical lead of the Southampton Musculoskeletal Research Unit. Professor Edwards also serves as Associate Editor for Rheumatology, and on the editorial board of Lupus.

Prof. Christopher Edwards (Bio)
Professor Burkhard Möller image
Professor Burkhard Möller

Professor of Rheumatology,
University of Bern, Bern, Switzerland

Professor Burkhard Möller is Leading Physician in the Department of Rheumatology, Clinical Immunology and Allergology at University Hospital (Inselspital), Bern, Switzerland. He is also Associate Professor of Rheumatology and Clinical Immunology in the Faculty of Medicine at the University of Bern.

Professor Möller gained his Master’s Degree at Hannover Medical University, Hannover, Germany. He became a lecturer in Internal Medicine and Rheumatology at the medical faculties of Frankfurt and of Bern, and gained Professorship at the University of Bern. Professor Möller holds titles from the Swiss Medical Association (Foederatio Medicorum Helveticorum [FMH]) in internal medicine, rheumatology, haematology and oncology.

As well as member of the American College of Rheumatology, Professor Möller is also member of the Swiss Society for Rheumatology, the Swiss Clinical Quality Management (SCQM) programme, and of the German Society of Rheumatology.

Professor Möller’s research interests include the pathogenesis of rheumatoid and psoriatic arthritis, anaemia of chronic disease, and musculoskeletal ultrasound in arthritis. He has published widely in journals including Rheumatology, Annals of the Rheumatic Diseases, Arthritis Research and Therapy, Arthritis & Rheumatology, and Arthritis Care & Research.

Prof. Burkhard Möller (Bio)
39:25 10
EULAR 2017 – Cardiovascular, and Malignancy & Infection
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
Professor Christopher Edwards image
Professor Christopher Edwards

Honorary Chair of Clinical Rheumatology,
University of Southampton, Southampton, UK

Professor Christopher Edwards is Consultant Rheumatologist and Honorary Chair of Clinical Rheumatology, University Hospital Southampton NHS Foundation Trust within Medicine at the University of Southampton. He graduated with honors from King's College London and trained at the Hammersmith and St George's Hospitals in London. He was a registrar for Professor Graham Hughes at the St Thomas' Hospital lupus unit and then undertook a period of research as a lecturer at the Kennedy Institute of Rheumatology at Imperial College under the supervision of Professor Ravinder Maini. He moved to Southampton in 2001 after working for a year as a rheumatology consultant at Tan Tock Seng Hospital in Singapore.

Professor Edwards is a clinical rheumatologist with research interests and expertise in the epidemiology and treatment of inflammatory rheumatic diseases including rheumatoid arthritis, lupus, psoriatic arthritis and ankylosing spondylitis.

He is a member of international committees working to produce guidelines for the best management of rheumatic diseases, leading a systematic review of guidelines for the use of radiology in the diagnosis and management of rheumatoid arthritis for EULAR. With expertise in the planning and delivery of trials in this area, including early stage trials, Professor Edwards has developed strong local and international partnerships with clinical and academic colleagues, centered on his role as clinical lead of the Southampton Musculoskeletal Research Unit. Professor Edwards also serves as Associate Editor for Rheumatology, and on the editorial board of Lupus.

Prof. Christopher Edwards (Bio)
30:15 10
EULAR 2017 – Clinical Combination Therapies, Temporary Stops, and Optimal Dosing
Professor Christopher Edwards image
Professor Christopher Edwards

Honorary Chair of Clinical Rheumatology,
University of Southampton, Southampton, UK

Professor Christopher Edwards is Consultant Rheumatologist and Honorary Chair of Clinical Rheumatology, University Hospital Southampton NHS Foundation Trust within Medicine at the University of Southampton. He graduated with honors from King's College London and trained at the Hammersmith and St George's Hospitals in London. He was a registrar for Professor Graham Hughes at the St Thomas' Hospital lupus unit and then undertook a period of research as a lecturer at the Kennedy Institute of Rheumatology at Imperial College under the supervision of Professor Ravinder Maini. He moved to Southampton in 2001 after working for a year as a rheumatology consultant at Tan Tock Seng Hospital in Singapore.

Professor Edwards is a clinical rheumatologist with research interests and expertise in the epidemiology and treatment of inflammatory rheumatic diseases including rheumatoid arthritis, lupus, psoriatic arthritis and ankylosing spondylitis.

He is a member of international committees working to produce guidelines for the best management of rheumatic diseases, leading a systematic review of guidelines for the use of radiology in the diagnosis and management of rheumatoid arthritis for EULAR. With expertise in the planning and delivery of trials in this area, including early stage trials, Professor Edwards has developed strong local and international partnerships with clinical and academic colleagues, centered on his role as clinical lead of the Southampton Musculoskeletal Research Unit. Professor Edwards also serves as Associate Editor for Rheumatology, and on the editorial board of Lupus.

Prof. Christopher Edwards (Bio)
Professor Burkhard Möller image
Professor Burkhard Möller

Professor of Rheumatology,
University of Bern, Bern, Switzerland

Professor Burkhard Möller is Leading Physician in the Department of Rheumatology, Clinical Immunology and Allergology at University Hospital (Inselspital), Bern, Switzerland. He is also Associate Professor of Rheumatology and Clinical Immunology in the Faculty of Medicine at the University of Bern.

Professor Möller gained his Master’s Degree at Hannover Medical University, Hannover, Germany. He became a lecturer in Internal Medicine and Rheumatology at the medical faculties of Frankfurt and of Bern, and gained Professorship at the University of Bern. Professor Möller holds titles from the Swiss Medical Association (Foederatio Medicorum Helveticorum [FMH]) in internal medicine, rheumatology, haematology and oncology.

As well as member of the American College of Rheumatology, Professor Möller is also member of the Swiss Society for Rheumatology, the Swiss Clinical Quality Management (SCQM) programme, and of the German Society of Rheumatology.

Professor Möller’s research interests include the pathogenesis of rheumatoid and psoriatic arthritis, anaemia of chronic disease, and musculoskeletal ultrasound in arthritis. He has published widely in journals including Rheumatology, Annals of the Rheumatic Diseases, Arthritis Research and Therapy, Arthritis & Rheumatology, and Arthritis Care & Research.

Prof. Burkhard Möller (Bio)
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
30:33 10
EULAR 2017 – Laboratory Science
Professor Burkhard Möller image
Professor Burkhard Möller

Professor of Rheumatology,
University of Bern, Bern, Switzerland

Professor Burkhard Möller is Leading Physician in the Department of Rheumatology, Clinical Immunology and Allergology at University Hospital (Inselspital), Bern, Switzerland. He is also Associate Professor of Rheumatology and Clinical Immunology in the Faculty of Medicine at the University of Bern.

Professor Möller gained his Master’s Degree at Hannover Medical University, Hannover, Germany. He became a lecturer in Internal Medicine and Rheumatology at the medical faculties of Frankfurt and of Bern, and gained Professorship at the University of Bern. Professor Möller holds titles from the Swiss Medical Association (Foederatio Medicorum Helveticorum [FMH]) in internal medicine, rheumatology, haematology and oncology.

As well as member of the American College of Rheumatology, Professor Möller is also member of the Swiss Society for Rheumatology, the Swiss Clinical Quality Management (SCQM) programme, and of the German Society of Rheumatology.

Professor Möller’s research interests include the pathogenesis of rheumatoid and psoriatic arthritis, anaemia of chronic disease, and musculoskeletal ultrasound in arthritis. He has published widely in journals including Rheumatology, Annals of the Rheumatic Diseases, Arthritis Research and Therapy, Arthritis & Rheumatology, and Arthritis Care & Research.

Prof. Burkhard Möller (Bio)
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
11:32 5
EULAR 2017 – Psoriatic Arthritis
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
15:13 5
Close
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
01:01
Evaluation 5

Date of preparation: 14 July 2017