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The Evolving Landscape of Small Molecule Inhibitors in Rheumatoid Arthritis

Developed by CESAS Medical, under the auspices of the University of Glasgow
This activity is supported by unrestricted educational grants from Lilly

Release date: 30 August 2019
Expiration date: 24 September 2021
Estimated time to complete activity: 1 and 1/2 hours
Compatible with all modern internet browsers and mobile devices

EDUCATIONAL OBJECTIVES
After completing this activity, the learner will be able to:
  • Review the updated safety data for approved JAK inhibitors
  • Review the data on JAK inhibitors in development
  • Discuss the biology of BTK inhibitors and their potential in the treatment of rheumatoid arthritis

TARGET AUDIENCE
This activity is designed for rheumatologists and other healthcare professionals involved in treating patients with rheumatic disease.

PROGRAMME OVERVIEW
This programme presents new research into cytokine signalling with a focus on approved and emerging JAK and BTK inhibitors, which are set to shape the ever-changing rheumatology treatment landscape. JAK inhibitors are now being marketed for the treatment of rheumatoid arthritis, with new JAK inhibitors on the horizon and new data for new cytokine signaling agents emerging. With ever evolving comparisons between current drugs and new agents in the pipeline, there is an educational need to keep up-to-date with ongoing research to understand the impact the latest data has on clinical practice.

In this activity, The Evolving Landscape of Small Molecule Inhibitors in Rheumatoid Arthritis, a panel of international experts discuss some of the latest papers and key abstracts from EULAR 2019 with a focus on cytokine signalling. Data, presented in 3 distinct modules, highlights JAK inhibitors in clinical practice, emerging JAK inhibitors in phase 3 trials and the potential of new BTK inhibitors as a new treatment for rheumatoid arthritis. The learner’s understanding of the information presented will be assessed following each of the course modules.

INSTRUCTIONS FOR PARTICIPATION
Participants must 1) read the activity information; 2) study the educational content; 3) successfully complete the post-module assessments with a score of ≥80%; 4) complete the evaluation form. Upon completion of the full activity, a certificate will be made available to download and print.

DISCLOSURE OF CONFLICTS OF INTEREST
CESAS Medical requires faculty, presenters, planners, managers, writers, and any other individuals who are in a position to influence the content of this activity to disclose any real and/or apparent conflict of interest (COI) they may have as related to the content of this activity. All identified COI are thoroughly reviewed and resolved according to CESAS Medical policy.

ACCREDITATION STATEMENT
The e-learning activity, The Evolving Landscape of Small Molecule Inhibitors in Rheumatoid Arthritis, organised by CESAS Medical, under the auspices of the University of Glasgow, is accredited by the European Accreditation Council for Continuing Medical Education (EACCME) to provide the following CME activity for medical specialists. The e-learning activity, The Evolving Landscape of Small Molecule Inhibitors in Rheumatoid Arthritis, organised by CESAS Medical, under the auspices of the University of Glasgow, is awarded 1 European CME credits (ECMECs) .

Each medical specialist should claim only those credits that he/she actually spent in the educational activity. The EACCME is an institution of the European Union of Medical Specialists (UEMS). Only those e-learning materials that are displayed on the UEMS-EACCME website have formally been accredited. Through an agreement between the European Union of Medical Specialists (UEMS) and the American Medical Association (AMA), physicians may convert EACCME credits to an equivalent number of AMA PRA Category 1 Credits. Information on the process to convert EACCME credit to AMA credit can be found at www.ama-assn.org/education/earn-credit-participation-international-activities.
Module Presenter Video Questions
Introduction
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
06:37
JAKinibs in Clinical Practice
Professor Johannes W.J. Bijlsma image
Professor Johannes W.J. Bijlsma

Professor and Head of the Department of Rheumatology and Clinical Immunology,
University Medical Centre, Utrecht, The Netherlands

Professor Hans Bijlsma obtained his medical degree and PhD from the University of Utrecht in 1974 and 1983, respectively, and has been a Professor of Rheumatology at the University since 1990.

Professor Bijlsma was Chairman of The European League Against Rheumatism (EULAR) Standing Committee on Education and Training from 2005 until 2009, and has been EULAR Educational Officer since 2009. He held a variety of posts at the Dutch Society for Rheumatology from 1992 until 2008, including Scientific Secretary, President and Chairman Consilium. He is Associate Editor of the Annals of Rheumatic Diseases and is on the editorial board of Osteoarthritis and Cartilage, Clinical and Experimental Rheumatology, Best Practice & Research Clinical Rheumatology and Clinical Rheumatology.

Professor Bijlsma has authored and co-authored more than 450 articles published in international peer-reviewed journals. He has also authored chapters for and is Editor of numerous books in the field of rheumatology. His research interests include the immune aspects of rheumatic diseases and osteoarthritis.

Prof. Johannes W.J. Bijlsma (Bio)
22:55 5
Emerging JAKinibs
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
45:53 13
Beyond JAKinibs: Potential New Cytokine Signalling Pathways
Professor Johannes W.J. Bijlsma image
Professor Johannes W.J. Bijlsma

Professor and Head of the Department of Rheumatology and Clinical Immunology,
University Medical Centre, Utrecht, The Netherlands

Professor Hans Bijlsma obtained his medical degree and PhD from the University of Utrecht in 1974 and 1983, respectively, and has been a Professor of Rheumatology at the University since 1990.

Professor Bijlsma was Chairman of The European League Against Rheumatism (EULAR) Standing Committee on Education and Training from 2005 until 2009, and has been EULAR Educational Officer since 2009. He held a variety of posts at the Dutch Society for Rheumatology from 1992 until 2008, including Scientific Secretary, President and Chairman Consilium. He is Associate Editor of the Annals of Rheumatic Diseases and is on the editorial board of Osteoarthritis and Cartilage, Clinical and Experimental Rheumatology, Best Practice & Research Clinical Rheumatology and Clinical Rheumatology.

Professor Bijlsma has authored and co-authored more than 450 articles published in international peer-reviewed journals. He has also authored chapters for and is Editor of numerous books in the field of rheumatology. His research interests include the immune aspects of rheumatic diseases and osteoarthritis.

Prof. Johannes W.J. Bijlsma (Bio)
18:35 4
Close
Professor Iain B. McInnes image
Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Prof. Iain B. McInnes (Bio)
Professor Johannes W.J. Bijlsma image
Professor Johannes W.J. Bijlsma

Professor and Head of the Department of Rheumatology and Clinical Immunology,
University Medical Centre, Utrecht, The Netherlands

Professor Hans Bijlsma obtained his medical degree and PhD from the University of Utrecht in 1974 and 1983, respectively, and has been a Professor of Rheumatology at the University since 1990.

Professor Bijlsma was Chairman of The European League Against Rheumatism (EULAR) Standing Committee on Education and Training from 2005 until 2009, and has been EULAR Educational Officer since 2009. He held a variety of posts at the Dutch Society for Rheumatology from 1992 until 2008, including Scientific Secretary, President and Chairman Consilium. He is Associate Editor of the Annals of Rheumatic Diseases and is on the editorial board of Osteoarthritis and Cartilage, Clinical and Experimental Rheumatology, Best Practice & Research Clinical Rheumatology and Clinical Rheumatology.

Professor Bijlsma has authored and co-authored more than 450 articles published in international peer-reviewed journals. He has also authored chapters for and is Editor of numerous books in the field of rheumatology. His research interests include the immune aspects of rheumatic diseases and osteoarthritis.

Prof. Johannes W.J. Bijlsma (Bio)
01:03
Evaluation 17

Date of preparation: 30 August 2019