Cytokine Signalling Forum

Publications





January 15

IL-6 stimulates intestinal epithelial proliferation and repair after injury

Kuhn KA, Manieri NA, Liu TC, Stappenbeck TS.
PLoS One. 2014 Dec 5;9(12):e114195. doi: 10.1371/journal.pone.0114195. eCollection 2014.

IL-6 is an inflammatory cytokine known to contribute to a number of autoimmune diseases such as RA. Therapies targeting the soluble IL-6 receptor have now become effective treatments for RA. However, one unforeseen, yet rare, potential complication of anti-IL-6 therapy is bowel perforation. Yet within the intestine, IL-6 protects intestinal epithelial cells from apoptosis during prolonged inflammation. The authors hypothesized that IL-6 may have beneficial properties in wound response/repair, s...

Keywords: IL-6, Preclinical, MOA