Cytokine Signalling Forum

Faculty




Steering Committee

Professor Iain B. McInnes image

Professor Iain B. McInnes

Muirhead Professor of Medicine, Director of the Institute of Infection, Immunity and Inflammation,
University of Glasgow, UK

Professor Iain McInnes studied medicine at the University of Glasgow and graduated with honours in 1989 before training in internal medicine and rheumatology. He completed his membership of the Royal College of Physicians (MRCP) in 1992 and became a fellow (FRCP) in 2003. He completed his PhD and post-doctoral studies via fellowships from the Wellcome Trust, the Arthritis Research Campaign (ARC, UK) and the National Institute of Health (NIH) Fogarty Fellowship Programme in both Glasgow and Bethesda, Maryland, USA.

Professor McInnes’ research interests include understanding the role of cytokines in inflammatory synovitis. He leads a trials unit specialising in the use of biologic agents in early clinical trials in inflammatory arthritis. Professor McInnes has published widely in the areas of immunobiology and rheumatology, and he is Associate Editor of Annals of Rheumatic Diseases and a member of the executive Editorial Board of the European Journal of Immunology. His work, together with that of his colleagues at the University of Glasgow, has been widely recognised and has received many prizes and lectureships including the Michael Mason Prize 2001 from the British Society for Rheumatology, the Albrecht Hasinger Lectureship 2002, the Nana Svartz Lectureship 2008, and the Dunlop Dotteridge Lectureship for the Canadian Rheumatology Association in 2010. He gave the British Society of Rheumatology (BSR) Droitwich Lecture in 2012, and the Gerald Weissmann Lecture in Rheumatology in New York in 2013. A previous Chairman of The European League Against Rheumatism (EULAR) Scientific Committee, he is now Liaison Officer to the American College of Rheumatology for EULAR. He was elected a fellow of the Royal Society of Edinburgh in 2008, and in 2012 was elected as a Fellow of the Academy of Medical Sciences.

Professor Johannes W.J. Bijlsma image

Professor Johannes W.J. Bijlsma

Professor and Head of the Department of Rheumatology and Clinical Immunology,
University Medical Centre, Utrecht, The Netherlands

Professor Hans Bijlsma obtained his medical degree and PhD from the University of Utrecht in 1974 and 1983, respectively, and has been a Professor of Rheumatology at the University since 1990.

Professor Bijlsma was Chairman of The European League Against Rheumatism (EULAR) Standing Committee on Education and Training from 2005 until 2009, and has been EULAR Educational Officer since 2009. He held a variety of posts at the Dutch Society for Rheumatology from 1992 until 2008, including Scientific Secretary, President and Chairman Consilium. He is Associate Editor of the Annals of Rheumatic Diseases and is on the editorial board of Osteoarthritis and Cartilage, Clinical and Experimental Rheumatology, Best Practice & Research Clinical Rheumatology and Clinical Rheumatology.

Professor Bijlsma has authored and co-authored more than 450 articles published in international peer-reviewed journals. He has also authored chapters for and is Editor of numerous books in the field of rheumatology. His research interests include the immune aspects of rheumatic diseases and osteoarthritis.

Professor Maurizio Cutolo image

Professor Maurizio Cutolo

Professor of Medicine and Rheumatology, Director of the Research Laboratory and Academic Unit of Clinical Rheumatology, Director of the Postgraduate School of Rheumatology,
University of Genova, Italy

Professor Maurizio Cutolo received his medical degree from Naples University in 1978. He is President-elect of The European League Against Rheumatism (EULAR), incoming President of the International League against Rheumatism (ILAR), and was previously the Chairman-elect of the EULAR Standing Committee for Education and Training (ESCET) between 2008 and 2012. Professor Cutolo has been Vice-President of the Italian Society for Rheumatology (SIR) and is a member of the Scientific Board of the American Autoimmune Related Diseases Association (AARDA) and the International Society for NeuroImmunoModulation (ISNIM). He was founder (1999) and Chairman, and is currently an Executive Committee member of the Study Group on Neuroendocrine Immunology (NEI), and founder and Chair of the Study Group on Capillaroscopy at the American College of Rheumatology (ACR). Professor Cutolo is also founder and Chairman of the EULAR Study Group on Neuroendocrine Immunology of Rheumatic Diseases (NEIRD) (2001–present). Professor Cutolo is an honorary member of the Russian and Hungarian Societies for Rheumatology.

Professor Cutolo is Associate Editor of the Journal of Clinical and Experimental Rheumatology, and an editorial board member of Annals of the Rheumatic Diseases, Neuroimmunomodulation, Clinical and Developmental Immunology, Reumatismo, Autoimmunity Review, Journal of Autoimmunity, and Revista Portuguesa de Reumatologia.

Professor Cem Gabay image

Professor Cem Gabay

Professor, Service of Rheumatology,
University Hospitals of Geneva, Switzerland

Dr Cem Gabay was trained in Internal Medicine and Rheumatology in Switzerland and in Paris, France. He worked as a research fellow and then as Assistant Professor in the laboratory of Professor W.P Arend at the University of Colorado Health Sciences Center, Denver, USA. Dr Gabay was appointed as Head of the Division of Rheumatology in 2001, and is currently also Chairman of the Department of Internal Medicine Specialties since 2013.

He is an expert in the field of IL-1 cytokines and acute-phase responses. Dr Gabay's clinical interests are focused on rheumatoid arthritis. He has performed several comparative studies on drug effectiveness using the data from the Swiss Clinical Quality Management registry on rheumatoid arthritis, and has led one of the first head- to-head clinical trials on biological agents in rheumatoid arthritis. He has published more than 200 original and review articles.

Dr Gabay was President of the Swiss Society of Rheumatology from 2008 to 2012, and has been the recipient of several awards from the Swiss Society of Rheumatology, EULAR, the International Cytokine Society, and the Medicine-Biology award from the University of Istanbul. He is member of the Editorial board of several scientific Journals.

Professor Juan J. Gómez-Reino image

Professor Juan J. Gómez-Reino

Head of the Department of Rheumatology,
University Hospital, Santiago de Compostela, Spain

Professor Juan Gómez-Reino completed his medical and doctor of philosophy degrees at the University of Madrid, Spain and his postgraduate training in internal medicine and rheumatology at the New York State University, Stony Brook, USA. He was formerly chief of the Department of Research and Section of Rheumatology at Hospital Doce de Octubre, Madrid, Spain.

Professor Gómez-Reino’s main clinical interest is chronic inflammatory arthropathies, and his experimental research is in the genetics of complex diseases, the effect of neuropeptides on chondrocyte function, and arthritis in animal models. He has authored or co-authored a number of original articles and papers in the areas of rheumatoid arthritis, spondyloarthritis and other rheumatology-specific disorders.

Associate Prof. Laure Gossec image

Associate Prof. Laure Gossec

Associate Professor of Rheumatology,
Université Pierre et Marie Curie and Hôpital Pitié-Salpêtrière, Paris, France

Professor Laure Gossec received her medical and rheumatology specialist degree from Paris University in 2002. She holds a Master's degree and a PhD in clinical epidemiology, obtained in 2008 on the subject of 'composite criteria in rheumatology'. In the clinic in Paris, she is responsible for the day-hospitalisation section where patients are treated with biologics.

Professor Gossec’s research interests include outcome measures in clinical trials, prediction of disease and severity, and the use of biologics in rheumatoid arthritis (RA). She also has expertise in meta-analyses. Professor Gossec has authored or co-authored more than 140 research papers, mainly relating to RA, psoriatic arthritis and spondyloarthritis. She is particularly interested in the patient’s perspective, and was the facilitator of a European League Against Rheumatism (EULAR) initiative developing a patient-derived weighted score to assess the impact of RA, known as the RAID (RA Impact of Disease) score. Professor Gossec is now leading a similar EULAR project in psoriatic arthritis.

Professor Ahmet Gül image

Professor Ahmet Gül

Principal Investigator of the Pilot Study and Professor of Medicine,
Istanbul University, Istanbul, Turkey

Ahmet Gul is a Professor of Rheumatology at the Istanbul Faculty of Medicine, Istanbul University, Turkey. Professor Gul’s research areas include: Behçet's disease and immunologic and genetic aspects in its pathogenesis; molecular genetics of familial Mediterranean fever (FMF); complex genetic disorders and genetic susceptibility in the pathogenesis of rheumatic disorders.

In 1995, Professor Gul won the Sedat Simavi Award followed by the Turkish Academy of Sciences Successful Young Scientists Award (2001). He was awarded the Istanbul University Research Fund Meliha Terzioglu Award (2001), and the Scientific and Technological Research Council of Turkey (TUBITAK) Junior Science Award (2004). Professor Gul is a member of the Rheumatism Society (Istanbul) and the Society for Research and Education in Rheumatology. He is also member of the Turkish Society of Immunology, and Chairman of the Behcet's Disease Society of Turkey. Professor Gul is also a member of the International Society for Behçet's Disease.

Professor Pierre Miossec image

Professor Pierre Miossec

Professor of Clinical Immunology,
Hôpital Edouard Herriot, Lyon, France

Professor Pierre Miossec received his medical degree from Brest University Hospital in 1983, and then worked as a research fellow at the Department of Internal Medicine, Rheumatic Diseases Unit, University of Texas. He received his PhD in Immunology from the University of Marseille in 1987 before going on to work as Associate, and later Professor, of Clinical Immunology at the Claude Bernard University, Lyon.

Professor Miossec’s main research interests include the role of cytokines and T cells in arthritis. He was part of the group to first identify interleukin-1 in the synovial fluid of patients with rheumatoid arthritis. He was also the first to identify the destructive properties of interleukin-17, and to introduce the concept of its production by a new T cell subset. He received the prestigious Carol Nachman prize in 2010 for this contribution. Professor Miossec is an editorial board member of many journals in the field of arthritis.

Professor John J. O'Shea image

Professor John J. O'Shea

Director, NIAMS Intramural Research Program,
NIAMS, Bethesda, Maryland, USA

John J. O'Shea, M.D., graduated Phi Beta Kappa with a Bachelor of Science degree from St. Lawrence University, and received a Doctor of Medicine degree from the University of Cincinnati. He then served as an intern and resident in Internal Medicine at the State University of New York Upstate Medical University in Syracuse, New York. Dr O'Shea joined the National Institutes of Health (NIH) in 1981 for subspecialty training in Allergy and Immunology in the National Institute of Allergy and Infectious Diseases. He did additional postdoctoral work in the Cell Biology and Metabolism Branch in the National Institute of Child Health and Human Development. Dr O’Shea is board certified in Internal Medicine and Allergy and Immunology.

He moved to the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) in 1994 as Chief of the Lymphocyte Cell Biology Section of the Arthritis and Rheumatism Branch. He was appointed Chief of the Molecular Immunology and Inflammation Branch in 2002, and became Scientific Director and Director of the NIAMS Intramural Research Program in 2005.

Dr O'Shea has served on the editorial boards of multiple journals, including: Immunity, Journal of Experimental Medicine, Journal of Biological Chemistry, Journal of Immunology, and Blood. He has been an invited lecturer at numerous universities and international meetings in the U.S., Canada, Europe and Asia.

Dr O'Shea has authored more than 225 articles. His area of scientific interest is cytokine signal transduction, dissecting the role of Jaks and Stats family transcription in immunoregulation. Dr O'Shea and his colleagues cloned the tyrosine kinase, JAK3, and demonstrated its role in pathogenesis of severe combined immunodeficiency.

Professor Georg Schett image

Professor Georg Schett

Director of the Department of Internal Medicine III and Institute for Clinical Immunology,
University of Erlangen-Nuremberg, Erlangen, Germany

Professor Georg Schett studied medicine at the University of Innsbruck, Austria, graduating in 1994. He then completed his post-doc research fellowship at the Institute for Biomedical Aging Research of the Austrian Academy of Science in Innsbruck in 1996. Between 1996 and 2001, he undertook his training in internal medicine and rheumatology at the Department of Internal Medicine III, Medical University of Vienna, Austria. He has been a specialist in internal medicine since 2001 and rheumatology/immunology since 2003. Since 2006, he has been Professor and Chairman of the Department of Internal Medicine III, Rheumatology and Clinical Immunology at Friedrich-Alexander University Erlangen-Nuremberg (EULAR Center of Excellence).

Professor Schett’s main clinical interests include the diagnosis and treatment of rheumatic diseases. His research interests include the pathogenesis of rheumatoid arthritis and the molecular basis of immune-mediated diseases. He has published more than 350 research articles and received numerous awards in his field including the National Award for Rheumatology Research in 2000, the START Award of the Austrian Science Fund (FWF) in 2003, the Bilroth Award in 2004, and the ESCI Award for Excellence in Clinical Research in 2011. In 2004, Professor Schett worked as a scientist in the pharmaceutical industry. He holds guest professorships at the University of San Diego Medical School, USA (2009), the University of Guangzhou, China and the University of Xian, China (2012). He is an active member of several national and international societies, and serves on the editorial board of several journals including Arthritis and Rheumatism and Annals of Rheumatic Diseases. He is Chairperson of the European League Against Rheumatism (EULAR) Standing Committee on Investigative Rheumatology.

Associate Professor Kevin Winthrop image

Associate Professor Kevin Winthrop

Associate Professor of Infectious Diseases, Public Health and Preventive Medicine, and Ophthalmology,
Oregon Health and Science University, USA

Professor Kevin Winthrop received his undergraduate degree in biology from Yale University and completed his MD degree at Oregon Health Sciences University in Portland, Oregon, USA. He obtained a masters degree in epidemiology at University California at Berkeley and completed an infectious disease epidemiology fellowship with the US Centers for Disease Control and Prevention (CDC) before serving as a staff member at CDC. He has co-authored more than 100 publications, many detailing epidemiologic and clinical aspects of infections and other adverse events associated with immune-mediated inflammatory diseases, particularly those related to biologic immunosuppressive therapies. Professor Winthrop also serves on the editorial board of Annals of Rheumatic Diseases, as Section Editor of Current Rheumatology Reports, and as an Associate Editor of BMC Infectious Diseases.




Additional Faculty

Professor Leonard Calabrese image

Professor Leonard Calabrese

Director & Professor of Medicine,
RJ Fasenmyer Center for Clinical Immunology, Cleveland Clinic Foundation, Ohio, USA

Dr Leonard Calabrese is a Professor of Medicine at the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, and Vice Chair of the Department of Rheumatic and Immunologic Diseases. Dr Calabrese is the Director of the RJ Fasenmyer Center for Clinical Immunology at the Cleveland Clinic specialising in diseases of the immune system, in particular, immunodeficiency diseases including HIV. Dr Calabrese has extensively published on the safety of biologic therapies for autoimmune diseases including the epidemiology of opportunistic and viral infections including PML. Dr Calabrese is also the Co-director of the Center for Vasculitis Care and Research and holds a joint appointment in the Department of Infectious Diseases.

Dr. Calabrese has lectured nationally and internationally on the subjects of clinical immunology, rheumatology and virology, and is the author of more than 400 published peer reviewed articles, book chapters and reviews.

Professor Ernest Choy image

Professor Ernest Choy

Director of the Cardiff Regional Experimental Arthritis Treatment and Evaluation (CREATE) Centre,
Cardiff University School of Medicine, Cardiff, Wales, UK

Professor Ernest Choy is Head of Rheumatology and Translational Research at the Institute of Infection and Immunity, and Director of the Cardiff Regional Experimental Arthritis Treatment and Evaluation (CREATE) Centre at Cardiff University School of Medicine, Cardiff, Wales, UK. He is also Honorary Consultant Rheumatologist at University Hospital of Wales, and Clinical Lead of the Welsh Arthritis Research Network (WARN). Previously, he was Reader and Director of the King’s Musculoskeletal Clinical Trials Unit in the Academic Department of Rheumatology, King’s College London. His major research interest is the treatment of rheumatic diseases focusing on the efficacy of new treatment strategies. He was Director of Research and Development at King's College Hospital between 2003 and 2008.

Professor Choy is a member of the European League Against Rheumatism (EULAR) Committee Standing Committee for International Clinical Studies Including Therapeutic Trials. He chairs the EULAR Taskforce on developing recommendations for management and classification criteria for fibromyalgia. Professor Choy has served as clinical expert to the National Institute for Clinical Excellence in the UK, and many pharmaceutical companies. He has published widely on treatments for rheumatic diseases in major medical journals such as The New England Journal of Medicine. He is a frequent lecturer on the treatment of rheumatic diseases.

Professor Simon Jones image

Professor Simon Jones

Associate Director for I&I Research,
University of Cardiff

Professor Simon Jones is currently Deputy Director for the Division of Infection and Immunity at the School of Medicine in Cardiff University where he leads the inflammation research group. He has a PhD in Biochemistry from Bristol University. Professor Jones has since developed a research programme focused on the cytokine pathways that determine balance between competent host defence and inflammation induced tissue damage. Studies explore the control of innate and adaptive immunity, and the contribution of stromal tissue in determining disease outcomes.

Professor Tsutomu Takeuchi image

Professor Tsutomu Takeuchi

Professor of Rheumatology, Keio University School of Medicine,
Keio University

Professor Tsutomu Takeuchi completed his medical education at Keio University School of Medicine and is currently Professor of Medicine in the Department of Internal Medicine at the same institution. His major research interests are molecular pathogenesis of systemic autoimmune diseases, targeted therapy in systemic autoimmune diseases, and prediction of therapeutic response. Professor Takeuchi has published more than 100 articles in peer-reviewed journals including Arthritis & Rheumatism, Annals of the Rheumatic Diseases, The Journal of Immunology, The Journal of Rheumatology, and The Journal of Clinical Investigation. Professor Takeuchi serves or has served as an editorial board member of the following journals: Rheumatology, Clinical Rheumatology, Clinical Immunology, and Modern Rheumatology. As a reviewer, he is currently serving for Nature Reviews of Immunology, The Lancet, Arthritis & Rheumatism, Annals of the Rheumatic Diseases, Rheumatology, Arthritis Research & Therapy, The Journal of Rheumatology, The Journal of Clinical Rheumatology, APLAR Journal of Rhematology, Modern Rheumatology, The Journal of Immunology, European Journal of Immunology, International Immunology, and The American Journal of Pathology.

Professor Peter Taylor image

Professor Peter Taylor

Norman Collisson Professor of Musculoskeletal Sciences,
University of Oxford, UK

Professor Peter Taylor studied pre-clinical medical sciences at Gonville and Caius College at the University of Cambridge where he earned his first degree in Physiology. He subsequently studied clinical medicine at the University of Oxford and was awarded a PhD degree from the University of London for studies on pathogenesis of arthritis. In October 2011, Professor Taylor was appointed Norman Collisson Chair of Musculoskeletal Sciences at the University of Oxford and is a Fellow of St. Peter's College, Oxford. He is the Head of Clinical Sciences at the Botnar Research Centre where he directs the Biomedical Research Unit Inflammation theme and leads the rheumatology clinical trials group and related translational research programme at the Kennedy Institute of Rheumatology within the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences.

Professor Taylor's specialist clinical interests include rheumatoid arthritis and early inflammatory arthritis. He has over 20 years' experience in clinical trial design and international leadership in studies of biologic and small molecular therapies in rheumatoid arthritis and ankylosing spondylitis. Professor Taylor has been principal investigator in numerous international clinical trials of biologic therapies including the earliest seminal trials of anti-TNF and anti-IL-6 receptor therapy, and is currently chief investigator in a number of small molecule therapies in clinical trials for rheumatoid arthritis and ankylosing spondylitis.

Professor Douglas Veale image

Professor Douglas Veale

Principal Investigator at The Conway Institute for Biomedical and Biomolecular Research,
University College Dublin (UCD), Ireland

Douglas J. Veale is a Professor of Medicine, Director of Translational Research at DAMC, Consultant Rheumatologist at St Vincent’s University Hospital, and Fellow and Principal Investigator at The Conway Institute for Biomedical and Biomolecular Research, University College Dublin (UCD). He is a Fellow of both the Royal College of Physicians in Ireland (1997) and the Royal College of Physicians, London (1999). Professor Veale graduated from the Royal College of Surgeons in Ireland in 1984 and obtained his MD by thesis from UCD in 1992.

Professor Veale has established an international reputation in translational research in the areas of early arthritis, biopharmaceutical therapy, biomarkers and scleroderma. He has established an excellent research team including senior scientists, post-doctoral scientists, clinical research fellows and PhD students funded by peer-reviewed grants from The American Federation for Ageing Research, The European Union FP6 and an FP7 funded Innovative Medicines Initiative (IMI), The Health Research Board of Ireland, Science Foundation Ireland, the Programme for Research in Third Level Institutions and several industry partnership programmes.

Professor Veale’s primary research interests include inflammatory arthritis – rheumatoid/psoriatic arthritis, novel biopharmaceutical therapy and biomarkers.