Cytokine Signalling Forum

Publications





May 18

Farmacocinética de Upadacitinib con Regímenes Clínicos de Formulación de Liberación Extendida Utilizados en Ensayos Clínicos Fase 3 de Artritis Reumatoide

Mohamed MEF, Zeng J, Marroum PJ, Song IH, Othman AA.
Clin Pharmacol Drug Dev. 2019 Feb;8(2):208-216. doi: 10.1002/cpdd.462

Upadacitinib (UPA) extended release (ER) formulation dosing achieved the target profile that enables single dosing in patients with RA. In early clinical studies, UPA was given as an immediate release (IR) formulation, however patients were noted to experience fluctuations in blood plasma concentrations. To enhance patient compliance in UPA Phase 3 trials, ER tablets have been developed. Here, authors aimed at characterising the pharmacokinetics of UPA single and multiple doses of ER compared ...

Keywords: JAK, Upadacitinib, Preclinical, PK-PD