Cytokine Signalling Forum


February 14

Konvansiyonel DMARD, Glukokortikoidler ve Tofasitiniblerin etkinliği: RA tedavisinde EULAR 2013 önerileri hakkında bilgilendiren sistematik literatür derlemesi

Gaujoux-Viala C, Nam J, Ramiro S.
Ann Rheum Dis doi:10.1136/annrheumdis-2013-204588

Systematic literature reviews were undertaken to assess the efficacy of csDMARDs, glucocorticoids and tofacitinib in the treatment of RA. The first two were updates to reviews conducted for the 2010 recommendations while the tofacitinib SLR was a complete review. Two studies identified by the csDMARD SLR, tREACH and TEAR, compared efficacy between MTX mono- and combination therapy (MTX+SSZ+HQ). Both of these studies found there was no benefit to immediate triple therapy. Further studies analysin...

Keywords: Cytokine Signalling, Clinical, Efficacy

Translated by: Bahtiyar Toz

Sentetik ve biyolojik DMARDların güvenliği: Romatoid artrit tedavisinde EULAR önerilerinin 2013 güncellemesini bildiren bir sistematik literatür incelemesi

Ramiro S, Gaujoux-Viala C, Nam JL et al.
Ann Rheum Dis doi:10.1136/annrheumdis-2013-204575

Two systematic literature reviews were undertaken to update the safety findings on synthetic and biological DMARDs in order to inform the updates to the EULAR recommendations to the treatment of RA. Of 10,559 articles screened, 49 were included for review covering a diverse range of outcomes. In the main these showed the patients on bDMARDs had a significantly greater risk of serious infections and tuberculosis compared with csDMARDs, while differences in data between studies mean a slight incr...

Keywords: Cytokine Signalling, Clinical, Safety

Translated by: Şafak Mirioğlu