Cytokine Signalling Forum

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December 16

TNF Inhibitörlerine Yetersiz Yanıtlı Aktif Romatoid Artrit Hastalarında Tofasitinib ve Biyolojik Tedavilerin Karşılaştırılması: Bir Network Meta Analizinin Sonuçları

Vieira M-C, Zwillich SH, Jansen JP, Smiechowski B, Spurden D and Wallenstein GV.
Clin Ther 2016;38:2628–40.

This network meta-analysis, performed within a Bayesian framework, concluded that tofacitinib 5 mg BID has efficacy and AE rates comparable with currently available bDMARDs over a 24-week period in patients experiencing an inadequate response to TNF therapy. A systematic literature search identified five, Phase 2 or beyond, randomised controlled trials for inclusion in the analysis. Each trial had an adult population with moderate to severe RA, with inadequate response (IR) or failed treatment...

Keywords: JAK, Tofacitinib, Clinical, Efficacy

Translated by: Bahtiyar Toz