Cytokine Signalling Forum

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June 14

Alternative p38 MAPKs Are Essential for Collagen-Induced Arthritis

Criado G, Risco A, Alsina-Beauchamp D et al.
Arthritis and Rheumatology Vol66, No. 5, May2014 pp 1208-1217

MAPK family proteins are regulatory proteins, affecting processes such as synthesis and release of proinflammatory molecules which contribute to the pathogenesis of RA. In particular, the p38 MAPK protein family is central to proinflammatory cytokine production. There are four member of the p38 group; p38α, p38β, p38γ and p38δ. This study sought to evaluate p38γ and p38δ deficiency in mice CIA model. In p38γ-/- or p38&delt...

Keywords: Cytokine Signalling, Preclinical, MOA