Cytokine Signalling Forum

Publications





April 21

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

Estupiñán HY, Berglöf A, Zain R, Smith CIE.
Front. Cell Dev. Biol. 9:630942 DOI: 10.3389/fcell.2021.630942

Understanding of the B-cell receptor signalling pathway led to the identification of a suitable drug target to addresses autoimmunity and inflammation in areas such as MS, RA, pemphigus and SLE. There are currently 22 BTKis in various stages of clinical development. However, AEs such as cardiovascular and bleeding side effects, as well as rash, diarrhoea and infections have been associated with the inhibition of other kinases with a BTKi-binding cysteine in their catalytic domain. Based on clini...