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Resultados Informados por los Pacientes (PROs) desde un Estudio Fase 3 de Baricitinib contra Placebo o Adalimumab en Artritis Reumatoide: Análisis secundario del estudio RA-BEAM

Keystone EC, Taylor PC, Tanaka Y, Gaich C, DeLozier AM, Dudek A, Velasco Zamora J, Covarrubias Cobos JA, Rooney T, de Bono S, Arora V, Linetzky B, Weinblatt ME. - Ann Rheum Dis 2017;76(11):1853-1861. doi: 10.1136/annrheumdis-2017-211259

This paper describes the patient-reported outcome (PRO) data collected in RA-BEAM, a Phase 3 study of baricitinib compared with both placebo and adalimumab in patients with RA and an inadequate response to MTX.

PRO measures evaluated include health-related quality of life (HRQOL), physical function, disability, fatigue, sleep, mental health status, work productivity and work activity impairment.

The RA-BEAM study demonstrated that patients treated with baricitinib experienced a greater improvement compared with patients treated with placebo or adalimumab in most PROs across different domains of RA, including physical function, morning joint stiffness, fatigue, pain and HRQOL. These improvements tended to occur within the first weeks of treatment and were maintained throughout the 52-week trial.

These data demonstrate treatment benefits, for patients receiving baricitinib, that appear clinically relevant.

Keywords: JAK, Baricitinib, Clinical, PRO

Access original article via Pubmed

Upload date: September 2017

Translated by: Igor Kos

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