JAK/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis
The JAK/STAT pathway is receiving increasing attention in modulation of nociceptive responses, given its clear role in cytokine signalling. The authors of this review speculate that JAKinibs may have an effect on the modulation of nociception and reduction of pain.
Crispino N, et al. review the impact of pain in patients with rheumatic disease and the physiological basis of modulating nociceptive pain. They examine the role of cytokines in the modulation of pain and analyse current clinical JAKinib data on pain modulation in the treatment of RA and PsA.
They conclude that it is possible to speculate that JAKinibs may have a dual therapeutic role in both modulation of inflammation, producing the observed clinical benefits, and modulation of nociception, which leads to a pain reduction beyond that related to inflammation.