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Showing 1 result for “Ӧstӧr AJK”.

February 2018

Reducir versus Mantener Metotrexate en concentración Estable en Combinación con Tocilizumab en Artritis Reumatoide: un Ensayo Aleatorizado, Doble Ciego.

Rheumatology (Oxford) 2018;57(1):84–91

Methotrexate (MTX) tapering in patients with active, severe RA receiving intravenous tocilizumab (TCZ) was non-inferior to continuing stable MTX doses in maintaining a good/moderate EULAR response. Although MTX and bDMARD combination therapy may produce better response rates than bDMARD monotherapy, one third of patients discontinue or are non-compliant with MTX due to preference or toxicity. This randomised, non-inferiority study investigated the efficacy and tolerability of MTX tapering and ma...