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August 2023

Filgotinib modula los biomarcadores proteicos de la sangre periférica asociados a la inflamación en adultos con artritis reumatoide activa y respuesta previa inadecuada al metotrexato

Rheumatol Ther. 2023 doi 10.1007/s40744-023-00583-9 Epub ahead of print

This study by Tanaka, et al. shows that filgotinib reduces peripheral protein biomarkers associated with JAK/STAT signalling, inflammatory signalling, immune cell migration, and bone resorption in RA patients. Notably, filgotinib 200 mg significantly reduced IL-6, TNF, CXCL13 levels as early as Week 4.