Effets indésirables de la grippe chez les patients atteints de polyarthrite rhumatoïde, de rectocolite hémorragique ou de rhumatisme psoriasique dans le cadre des programmes de développement clinique du tofacitinib
Rheumatol Ther. 2022. Epub ahead of print doi: 10.1007/s40744-022-00507-z
This post-hoc analysis of 31 clinical trials in ulcerative colitis, rheumatoid arthritis and psoriatic arthritis concludes that combined influenza adverse event incidence rates were highest in ulcerative colitis, while in each indication they were generally similar across tofacitinib, placebo, and comparator groups.
Reactivation of hepatitis B virus infection in patients with rheumatoid arthritis receiving tofacitinib
Int J Rheum Dis. 2021. Epub ahead of printTofacitinib could induce Hepatitis B virus (HBV) reactivation in RA patients.With previous studies having already demonstrated that RA patients using biologic agents, might experience HBV reactivation leading to acute hepatitis, hyperbilirubinemia, and death, Wang, et al. aimed to investigate HBV reactivation in patients with RA receiving tofacitinib. They found that Hepatitis B surface antigen positive patients receiving tofacitinib have a high incidence rate of HBV reactivation, which could be...