Impact des inhibiteurs de Janus kinase sur le risque d'événements cardiovasculaires chez les patients atteints de polyarthrite rhumatoïde: revue systématique et méta-analyse d'essais contrôlés randomisés
Ann Rheum Dis. 2019 Aug;78(8):1048-1054.Existing evidence from RCTs indicated no significant change in CV risk for JAK inhibitor (JAKinib) treated RA patients in a short-term perspective compared to placebo.Patients with RA have an elevated risk of CV morbidity and mortality, which cannot be fully explained by traditional CV risk factors. Reaching remission or LDA in order to reduce CV events (CVE) is encouraged in the current EULAR recommendations. JAKinibs and their roles in the modulation of CV risk remain undetermined. This study ...
Tuberculose, hépatite B et zona chez des patients atteints de polyarthrite rhumatoïde traités au Tofacitinib
Immunotherapy. 2019 Mar;11(4):321-333.The risk of TB and hepatitis B virus (HBV) appears to be no greater with TOF than with bDMARDs. Most cases of TB during TOF studies occurred in regions with high background rate of TB, including east Asian countries. TOF is also associated with a higher rate of herpes zoster (HZ) compared with bDMARDs. DMARDs used to treat RA can increase the risk of infections by causing a degree of immunosuppression. A range of bacterial and viral infections have been observed in association with DMARD therapy...