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Efficacy of Baricitinib in Treating Rheumatoid Arthritis: Modulatory Effects on Fibrotic and Inflammatory Biomarkers in a Real-Life Setting

Alessandro M, Perillo F, Refini R, Bergantini L, Bellisai F, Selvi E, Cameli P, Manganelli S, Conticini E, Cantarini L, Sestini P, Frediani B, Bargagli E. - Int Immunopharmacol. 2020 Sep;86:106748.

BARI demonstrated to be a safe immune modulator that reduces the concentrations biomarkers of lung fibrosis and inflammation in RA patients, including a subgroup with interstitial lung involvement. Professor Alessandro and colleagues analysed the effects of baricitinib in a population of RA and RA-ILD patients in a real-life setting, describing any changes in lung function parameters, serum inflammatory biomarkers and fibrotic biomarkers after 6 months of treatment.

Fifteen patients were recruited and eleven were treated with either 4 mg/day baricitinib monotherapy (11) or combination therapy (4) Patients were monitored for a period of six months, and were tested for lung function, adipokines, and for KL-6 concentration, which is expressed in the lung by regenerating or injured alveolar type II cells.

BARI decreased the systemic inflammation of RA by lowering expression of IL-6 and CRP and reducing ESR and serum concentrations of adiponectin. However, there was an increase in concentrations of proinflammatory adipokines (including, adipsin, resistin and leptin). Finally, KL-6 concentrations were reduced by BARI, which reflects the stability of interstitial lung involvement.

In conclusion, baricitinib was demonstrated to be a safe immune modulator that reduces the concentrations biomarkers of lung fibrosis and inflammation in RA patients, including a subgroup with interstitial lung involvement.

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Upload date: October 2020

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