Cytokine Signalling Forum

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August 16

Tocilizumab ile Tedavi Edilen Romatoid Artrit Hastalarındaki Diğer Biyolojik veya Konvansiyonel Sentetik DMARD'larla Tedaviye Kıyasla Alt İntestinal Perforasyon Riskleri

Strangfeld A, Richter A, Siegmund B, Herzer P, Rockwitz K, Demary W, Aringer M, Meißner Y, Zink A, Listing J.
Ann Rheum Dis 2016;0:1–7 DOI 10.1136/annrheumdis-2016-209773.

This real-life study confirms findings from the tocilizumab (TCZ) clinical development program that IL-6 inhibition with TCZ may be associated with increased risk of lower intestinal perforation (LIP). Data were analysed from the RABBIT register of patients. The primary outcome was the incidence of LIPs in patients exposed to TCZ, csDMARDs, TNFis, abatacept, or rituximab. Thirty-seven LIPs were observed in 53,972 patient years. The proportion of patients who developed a LIP was higher in pat...

Keywords: IL-6, Tocilizumab, Real World, Gastrointestinal

Translated by: Bahtiyar Toz