Cytokine Signalling Forum

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September 16

Deneysel Artrit Tedavisinde Doğal İmmün İnhibitörü İnterlökin-37 Eklem ve Sistemik İnflamasyonu Azaltır

Cavalli G, Koenders M, Kalabokis V, Kim J, Tan AC, Garlanda C, Manovani A, Dagna L, Joosten LAB, Dinarello CA.
Rheumatology (Oxford) 2016; DOI 10.1093/rheumatology/kew325

IL-37, a member of the IL-1 family, has recently been characterised as a fundamental inhibitor of innate inflammation. This study examines the effects of recombinant IL-37 on joint inflammation and pathology in a mouse model of arthritis, and also explores its potential in the treatment of human joint inflammation. In this mouse model of experimental arthritis, short-term, low-dose treatment with IL-37 suppressed joint and systemic inflammation. Wild-type mice received three intraperitoneal dos...

Keywords: Cytokine Signalling, Preclinical, MOA

Translated by: Bahtiyar Toz